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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity, and it also helps to reduce the chance of bias in the results. However, too much heterogeneity can cause issues with the design of the trial.
Pragmatic Play Pragmatic Play, one of the major players in the live casino market, provides an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic experience in gambling as well as a broad range of virtual betting options. The company has also created several interactive game shows to make online gambling fun. Some of these shows feature live hosts, whereas others are hosted by famous personalities from the industry.
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Legality
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The goal of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are typically ordered by policymakers and practitioners to inform their decisions. They can also be a great method of determining the causality between the intervention and its effects. However, they should not be used as a substitute for explanatory trials.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a pragmatic study that include the recruitment process, the design and delivery of the intervention, and follow-up.
There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary-care settings.